For last decade (2009-2020)
Micro-/Nanofluidics: Small Chip but Big World!
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Microfluidics and Nanofluidics (MNF) deal with fluid mechanics and mass transport phenomena at micro-/nanoscale. Unlike classical fluid mechanics and heat and mass transfer, the MNF are a multi-disciplinary field including engineering, physics, chemistry, biochemistry, and biotechnology and show a variety of novel applications.
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![](https://static.wixstatic.com/media/61914e_c2347b8dd029413583b1618dc880ffef~mv2.png/v1/fill/w_277,h_180,al_c,q_85,usm_0.66_1.00_0.01,enc_auto/61914e_c2347b8dd029413583b1618dc880ffef~mv2.png)
![](https://static.wixstatic.com/media/61914e_cbf4e0ba23c84e8c9b51e3b92f23cfe0~mv2.jpg/v1/fill/w_351,h_109,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/61914e_cbf4e0ba23c84e8c9b51e3b92f23cfe0~mv2.jpg)
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M. Kim and T. Kim*, Diffusion-based and long-range concentration gradients of multi-chemicals for bacterial chemotaxis assays, Anal. Chem., 82(22), pp. 9401-9409, 2010.
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Minseok Kim†, Ji Won Lim†, Hyun Ju Kim, Sung Kuk Lee, Sang Jun Lee*, and Taesung Kim*, Chemostat-like Microfluidic Platform for Highly Sensitive Detection of Heavy Metal Ions Using Microbial, Biosensors and Bioelectronics, 2015, 65(15), 257-264.
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Seongyong Park, Dasol Kim, Robert J. Mitchell, and Taesung Kim*, A Microfluidic Concentrator Array for Quantitative Predaton Assays of Predatory Microbes, Lab-on-a-chip, 2011.
Mixed-scale Patterning (micro-/nanofabrication) : Cracking is Breaking!
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Nano-scale patterns can be simultaneously produced with micro-scale patterns by using only the standard photolithography, showing a wide variety of micro-/nanofluidic applications. It is called "Crack-photolithography".
![](https://static.wixstatic.com/media/61914e_eabca37368e24ae0aa5593d28330f332~mv2.png/v1/fill/w_252,h_230,al_c,q_85,usm_0.66_1.00_0.01,enc_auto/61914e_eabca37368e24ae0aa5593d28330f332~mv2.png)
![](https://static.wixstatic.com/media/61914e_5ae02690a0d1471c99bbc57c6bbf94b2f000.jpg/v1/fill/w_65,h_60,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/61914e_5ae02690a0d1471c99bbc57c6bbf94b2f000.jpg)
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Minseok Kim, Dogyeong Ha, and Taesung Kim*, Cracking-assisted photolithography for mixed-scale patterning and nanofluidic applications, Nature Communications, 6, Article No. 6247, 2015.
Multi-physics Simulation : Complex but Visualizable!
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COMSOL Multiphysics Simulation visualizes the pre-concentration of target biomolecules at the anodic side (left) of the nanoporous, perm-selective memebrane patterned on the microchannel surface. This simulation deals with Navier-stokes's equation, Poisson's equation, and Nerst-Planct equation at the same time. It is called electrokinetics, showing remarkable potential for bio-sensor applications. The following simulation results show ion concentration polarization phenomena and nonlinear electroosmotic flow (the 2nd kind EOF flow).
![](https://static.wixstatic.com/media/61914e_5dbb7924960948e88bc7f749ff0dcaa9f000.jpg/v1/fill/w_112,h_70,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/61914e_5dbb7924960948e88bc7f749ff0dcaa9f000.jpg)
![](https://static.wixstatic.com/media/61914e_82ab7d279fd545119723912dfcb53329f000.jpg/v1/fill/w_112,h_70,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/61914e_82ab7d279fd545119723912dfcb53329f000.jpg)
![](https://static.wixstatic.com/media/61914e_5d9adb7334b546189256d9a6ef0d8d78f000.jpg/v1/fill/w_104,h_65,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/61914e_5d9adb7334b546189256d9a6ef0d8d78f000.jpg)
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Minseok Kim, Mingjie Jia and Taesung Kim*, Ion Concentration Polarization in A Single and Open Microchannel Induced by A Surface-patterned Perm-selective Film, Analyst, 2013, 138(5), 1370-1378.
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Mingjie Jia and Taesung Kim*, Multiphysics Simulation of Ion Concentration Polarization Induced By Nanoporous Membranes in Dual Channel Devices, Anal. Chem., 2014, 86(15), 7360−7367.
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Mingjie Jia and Taesung Kim*, Multi-physics Simulation of Ion Concentration Polarization Induced by A Surface-patterned Nanoporous Membrane in Single Channel Devices, Anal. Chem., 2014, 86(20), 10365–10372.
Mechatronics (automation of micro-/nanofluidic devices) :
Let's have the robot experiment!
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Micro-/nanofluidic devices can be automatically operated with the aid of LabVIEW and electric circuits (controller).
![](https://static.wixstatic.com/media/61914e_7695dbe0cf3345d5b396e42e279aec2b~mv2.gif)
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Jae Myung Lee, Jun Hyeong Lee, Taesung Kim* and Sung Kuk Lee*, Light-switchable gene expression system in Escherichia coli, PLOS One, 2013, 8(1): e52382.
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Younkwang Nam, Minseok Kim and Taesung Kim*, Pneumatically Controlled Multi-level Microchannel for Separation and Extraction of Microparticles, Sensors and Actuators: B-Chemicals, 2014, 190, 86-92. PDF (IF = 3.840)
Printing based micro-/nanofabrication : Make Things Show up!
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Inkjet-printing technology is employed to produce live cell patterns for high-throughput screening of small mutant libraries and nano-gratings for anti-counterfeit applications.
![](https://static.wixstatic.com/media/61914e_a0d8d5540950463f8502b9ba694abc84~mv2.jpg/v1/fill/w_83,h_51,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/61914e_a0d8d5540950463f8502b9ba694abc84~mv2.jpg)
[Materials Printer]
![](https://static.wixstatic.com/media/61914e_c8b0834871d943ffb88fa04ded81a132~mv2.png/v1/fill/w_52,h_28,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/61914e_c8b0834871d943ffb88fa04ded81a132~mv2.png)
![](https://static.wixstatic.com/media/61914e_0df38da3c34b44bcbf7a27107590e7fa~mv2.jpg/v1/fill/w_121,h_50,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/61914e_0df38da3c34b44bcbf7a27107590e7fa~mv2.jpg)
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Woon Sun Choi, Dokyeong Ha, Seongyong Park, and Taesung Kim*, Synthetic Multi-cellular Cell-to-Cell Communication in Inkjet Printed Bacterial Cell Systems, Biomaterials, 2011, 32 2500-2Hyunmoon Nam†, Kyungjun Song†, Dogyeong Ha and Taesung Kim*, Mono-layered Photonic Crystal Patterning for Anti-counterfeit Applications of Structural Colors, Scientific Reports, 2016, 6, Article number: 30885.
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Woon Sun Choi, Dokyeong Ha, Seongyong Park, and Taesung Kim*, Synthetic Multi-cellular Cell-to-Cell Communication in Inkjet Printed Bacterial Cell Systems, Biomaterials, 2011, 32 2500-2507.
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Woon Sun Choi, Minseok Kim, Seongyong Park, Sung Kuk Lee and Taesung Kim*, Patterning and Transferring Hydrogel-Encapsulated Bacterial Cells for Quantitative Analysis of Synthetically Engineered Genetic Circuits, Biomaterials, 2012, 33(2), 624-633. PDF
![](https://static.wixstatic.com/media/61914e_b4d2c389eb9d4972a1a942ba0dabbdc8f000.jpg/v1/fill/w_86,h_64,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/61914e_b4d2c389eb9d4972a1a942ba0dabbdc8f000.jpg)
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[Printing of Nanoparticle Suspension: mono-layered self-assembled nanoparticles]
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Hyunmoon Nam†, Kyungjun Song†, Dogyeong Ha and Taesung Kim*, Mono-layered Photonic Crystal Patterning for Anti-counterfeit Applications of Structural Colors, Scientific Reports, 2016, 6, Article number: 30885.